of eye drops
Okumetil is a combined drug containing zinc sulfate, diphenhydramine and naphazoline. These substances in Okumetil have antiseptic, anti-allergic and anti-inflammatory effects.
Zinc sulfate, when applied topically, has an astringent, drying, anti-inflammatory and antiseptic effect.
Nafazoline is a sympathomimetic. It has a rapid, pronounced and long-lasting vasoconstrictive effect. When applied topically, it reduces swelling and hyperemia of the mucous membranes.
Diphenhydramine is a blocker of H1-histamine receptors. When applied topically, it reduces the permeability of capillaries and prevents tissue edema.
When applied topically, it undergoes systemic absorption. There is no information about the degree of penetration into various eye tissues after topical application.
Chronic nonspecific conjunctivitis and blepharoconjunctivitis. Allergic conjunctivitis and blepharoconjunctivitis. Angular conjunctivitis. Redness, itching, foreign body sensation (reduction of symptoms of eye tissue irritation).
Method of administration and dosage
Okumetil should be instilled 1 drop into the conjunctival sac of the affected eye (eye) 2-3 times a day. If there is no decrease in symptoms during the use of the drug for 72 hours, you should consult a doctor.
Hypersensitivity to the components of the drug.
Dry eye syndrome.
Stenosing ulcer of the stomach and duodenum .
Stenosis of the neck of the bladder.
Cardiovascular diseases (CHD, arterial hypertension).
Hyperfunction of the thyroid gland.
Severe atherosclerosis .
Children under 2 years of age.
It is used with caution in patients taking MAO inhibitors or other drugs that increase blood pressure.
Okumetil: Side effects
After instillation, there may be a slight burning sensation, blurred vision, the development of allergic reactions. With aphakia, the development of maculopathy and the appearance of a central scotoma is possible. In this case, the withdrawal of the drug leads to the reverse development of symptoms. After topical use of naphazoline, which is part of Okumetil, reactive hyperemia and swelling of the eye mucosa, pupil dilation, increased IOP (intraocular pressure) may occur. With prolonged use, the phenomenon of tissue irritation occurs most often. Since when applied topically, naphazoline has a general resorptive effect, it is possible to develop tachycardia, increased blood pressure, nausea, headache. With topical application of diphenhydramine, side effects of both local and systemic nature may develop: paresis of accommodation, photosensitization, dryness and numbness of the mucous membrane of the eyes, drowsiness, weakness, decreased psychomotor reactions and impaired coordination of movements, dizziness. With prolonged use of zinc salts, dryness of the eye mucosa may occur.
Since it is possible to mutually reduce the effects of diphenhydramine and drugs that stimulate the central nervous system, it is not recommended to use the drug Okumetil in patients using these drugs. Okumetil should not be used simultaneously with MAO inhibitors and within 10 days after discontinuation of their administration. As a result of the combined use of beta-blockers, MAO inhibitors with adrenomimetics, the effect of the latter is enhanced. Naphazoline slows down the absorption of local anesthetics, so it is not recommended to use Okumetil together with local anesthetics used in ophthalmology. Zinc sulfate is not pharmacologically compatible with silver , lead , quinine , ichthyol, citral , protargol, alkaline-reacting substances.
Keep the bottle tightly closed and avoid contact of the tip of the pipette with any surface, in order to avoid contamination of the solution.
Influence on the ability to drive vehicles and manage mechanisms
Within 10-15 minutes after instillation, visual acuity may decrease, and therefore it is necessary to be careful when driving a car and when working with mechanisms.