Advantage Flea Tick Lice Drops Monthly Treatment Medication For X-Large Dogs NEW VetGuard Plus Flea and Tick Control for Extra Large Dogs kills fleas, flea eggs and larvae, lice and ticks and repels new fleas, ticks and mosquitoes for up to six weeks. The package includes four monthly applications for use on dogs over 66 pounds. VetGuard Plus for Dogs provides two active ingredients that work together to keep pesky invaders off and away from your dog. Permethrin – a powerful, fast-acting insecticide that kills and repels adult fleas, lice, ticks, and other invaders for up to four weeks with just one application. And, Pyriproxyfen (Nylar) – an insect growth regulator that targets and destroys flea larvae, keeping future generations off your dog. EPA Reg # 67505-3-88966- Kills and repels fleas, lice, mosquitoes, and ticks for up to 4 weeks- Product has demonstrated greater than 92% control of fleas within one day of application- Medication prevents flea eggs from developing into biting adults for up to 4 months- Waterproof, quick-acting, long-lasting monthly treatment- Control pesky pests and bites with this monthly spot on treatment