Serene - Contains a blend of ingredients important for mood and sleep-wake function* NeuroScience formulates and organizes products into the network impacted within their multi-system approach: Catecholamine, NeuroAdrenal, NeuroImmune, and Serotonin/GABA. Serene is part of the Serotonin/GABA line. The NeuroScience Approach Holistic formulations with blended ingredients offer comprehensive support that individual ingredients cannot. NeuroScience emphasizes the science behind symptoms and quality blended ingredients at impactful amounts, delivering consistent results. Formulations are based on published scientific journals and clinical studies that discuss safe and effective ingredients as well as the amount necessary for positive outcomes. †To see the science behind this product, refer to 'Building Connections' charts in the main product images. Growth Rooted in Neuroscience Established in the Saint Croix River Valley near Osceola, Wisconsin in 2000 as a privately-owned professional grade dietary supplement company, NeuroScience began offering proprietary blends of amino acids designed specifically to provide precursors for nervous system molecules called neurotransmitters. After nearly two decades, NeuroScience is recognized as a top pro-grade brand delivering premium products containing amino acids, botanicals, vitamins, and minerals exclusively to thousands of licensed healthcare providers. NeuroScience embraces the expectations of a rigorously regulated professional grade supplement brand. In addition to using inspected manufacturers that comply with current good manufacturing practices, NeuroScience orders impartial third-party testing to verify label ingredient amounts are met, inspect for microbial contaminants, and test for heavy metal contamination. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Contains a blend of ingredients important for mood and sleep-wake function* 5-HTP (from Griffonia simplicifolia seed extract): 5-hydroxytryptophan (5-HTP) crosses the blood-brain barrier and is a precursor to serotonin and melatonin [1].* Serotonin is important for regulating mood and sleep-wake function [2]. In a randomized, double-blind study, 5-HTP was shown to significantly improve mood [3].* Vitamins B and C: Active forms of vitamin B6, folate, and C are important for serotonin synthesis [4-8].* References: [1] Shaw K, et al. Cochrane Database Syst Rev. 2002;(1):CD003198. [2] Monti J. Sleep Med Rev. 2011;15(4):269-81. [3] Jangid P, et al. Asian J Psychiatr. 2013;6(1):29-34. [4] Dakshinamurti K, et al. Ann N Y Acad Sci. 1990;585:128-44. [5] Bottiglieri T. Psychiatr Clin North Am. 2013;36(1):1-13. [6] Stahl S. J Clin Psychiatry. 2008;69(9):1352-3. [7] Antoniades C, et al. Circulation. 2006;114(11):1193-201. [8] May J, et al. Brain Res Bull. 2013;90:35-42.